New drug for diabetes found to have heart protective potential
Posted March 20th, 2017, 12:28 PM IST
The drugs, known as SGLT-2 inhibitors, work by removing blood sugar via the urine and include Astra's Farxiga, Jardiance from Eli Lilly and Co and Boehringer Ingelheim, and Invokana from Johnson & Johnson.
Jardiance caused a stir in 2015, when a clinical trial conducted to reassure it does not cause heart problems instead showed it reduced the combined risk of hospitalization for heart failure or death from heart failure by 39 percent in high risk patients. The heart benefit has since been incorporated into Jardiance's label.
AstraZeneca is conducting its own large clinical trials to determine the heart effect of Farxiga with results expected in 2019.
But the latest data presented by Dr. Mikhail Kosiborod at the American College of Cardiology scientific meeting in Washington appears to indicate that heart protection is not limited to Jardiance.
"The fact that the results are remarkably consistent from country to country regardless of which compound predominates, that certainly seems to suggest that it's a class effect," said Kosiborod, a cardiologist from Saint Luke's Mid America Heart Institute in Kansas City. He noted that most Americans in the data were taking Invokana, while Farxiga was dominant in Europe.
The study, which analyzed data from more than 300,000 type 2 diabetes patients collected from six countries, found the SGLT-2 drugs slashed the combined risk of hospitalization for heart failure and death from any cause by 46 percent.
The data was obtained from real-world sources, such as medical records, claims databases and national registers. Most patients were taking Farxiga or Invokana with less than 10 percent on Jardiance. The comparator medicines included a wide variety of diabetes treatments, including metformin, DPP-4 inhibitors, such as Merck & Co's Januvia, and insulin, among others.
The vast majority of patients had no history of heart disease. But heart disease is the number one killer of people with diabetes, and mounting evidence of heart protective qualities of SGLT-2 drugs could lead to greater use.
"This class has a real potential of improving patient outcomes," Kosiborod said. Given the observational nature of the study the possibility of unmeasured confounding factors exists, researchers noted.
More than 400 million people worldwide have diabetes, of whom at least 90 percent have type 2.
- Kukatpally, Old City and Tolichowki made their mark as the city's top street food hubs
- Political leaders attend grand Alia Balai programme in Hyderabad
- Over 7,500 daily steps before surgery tied to fewer complications
- Deepika talks mental health with corporate bosses
- Sweet Shop - Owners of Calcutta and Other Ideas: Taste the universe
- Life in motion
- Witness The Most Riveting Courtroom Drama of The Year
- Mind-Body Synergy: Embracing Profound Connection Between Mental and Physical Health
- Red Haute Alert
- WWF-India Hosts Second Earth Series Talk: "A Tale of Two Cats"
- Hyderabad entrepreneurs ‘Modify’ clothes from aloe vera to orange peel
- How to Apply Onion Juice to Hair
- Patriotism is in thing, it’s Tricolour everywhere
- Celebs too wear fakes of reputed brands
- Elon Musk on fun trail says 'buying Coca Cola next'
More Lifestyle News
- Aditi Rao Hydari misses ‘Heeramandi’ event after wedding
- Bigg Boss winner Munawar Faruqui among 14 detained in Mumbai raid
- Mrunal Thakur follows ‘grandma diet,’ believes in not skipping meals
- Selena Gomez shares makeup-free selfies on Instagram
- Diljit collaborates with Saweetie for ‘Khutti’ Song, says ‘she just landed in Punjab’
- Malaika Arora, Arjun Kapoor, Richa, Ali Fazal, Farah, and more at KJo’s Bash
- Jamie Lever is ‘honoured’ to represent her heritage with Telugu debut film
- Janhvi and Aditya Roy Kapur shine on the ramp for Kalki at Lakme Fashion Week x FDCI
- I am fond of Kate Moss, says Diana Penty, about her fashion icon
- Kriti Kharbanda, Pulkit Samrat share pictures from dreamy wedding
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(): http:// wrapper is disabled in the server configuration by allow_url_fopen=0
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(http://www.indiaaffiliates.in/ads.php?size=300X250): failed to open stream: no suitable wrapper could be found
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once