Tuesday, December 12, 2017 |
Here are the 7 great escapes in prison historyJharkhand hosts open kissing contest for couples competing for longest kissFrom ad shoot, dating, heartbreak to marriage: Virat Kohli-Anushka Sharma love storySee photos and videos: Love takes over as Virat Kohli, Anushka Sharma marry in ItalyAnu Emmanuel for Ram Charan, NTR?Virat and Anushka get married, photos and videos from the weddingHyderabad: Another city resident falls victim to OLX online fraudBhavani island’s laser show to draw crowdsAndhra Pradesh: Jaggery prices dip ahead of festivalsAndhra Pradesh: Coast Guard gives safety tips to people

Novel cell replacement therapy may help cure diabetes

Posted May 12th, 2017, 02:53 PM IST

Novel cell replacement therapy may help cure diabetes

Washington D.C.: Good news for diabetics on insulin as a recent study has found that the novel tissue-engineered islet transplant offers hope.

Scientists from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have produced the first clinical results demonstrating that pancreatic islet cells transplanted within a tissue-engineered platform can successfully engraft and achieve insulin independence in type 1 diabetes.

The findings are part of an ongoing clinical study to test this novel strategy as an important step toward offering this life-changing cell replacement therapy to millions living with the disease.

Islet transplantation has demonstrated the ability to restore natural insulin production and eliminate severe hypoglycemia in people with type 1 diabetes. The insulin-producing cells have traditionally been implanted within the liver, but this transplant site poses some limitations for emerging applications, leading researchers to investigate other options.

DRI scientists have focused on the omentum, an apron-like tissue covering abdominal organs, which is easily accessed with minimally invasive surgery and has the same blood supply and physiological drainage characteristics as the pancreas.

"The objective of testing this novel tissue-engineered platform is to initially determine that insulin-producing cells can function in this new site, and subsequently introduce additional technologies towards our ultimate goal to replace the pancreatic endocrine function lost in type 1 diabetes without the need for anti-rejection drugs, what we call the DRI BioHub," explained researcher Camillo Ricordi.

This was the first successful tissue-engineered "mini pancreas" that has achieved long-term insulin independence in a patient with type 1 diabetes. The biological platform was made by combining donor islets with the patient's own (autologous) blood plasma, which was laparoscopically layered onto the omentum. Clinical-grade thrombin was then layered over the islet/plasma mixture. Together, these substances create a gel-like material that sticks to the omentum and holds the islets in place.

Over time, the body will absorb the gel, leaving the islets intact. The technique has been designed to minimize the inflammatory reaction that is normally observed when islets are implanted in the liver or in other sites with immediate contact to blood. The DRI's clinical trial, an important first step toward developing the BioHub mini organ, includes the immunosuppressive regimen currently used for clinical islet transplantation studies.

"The results thus far have shown that the omentum appears to be a viable site for islet implantation using this new platform technique," said lead author David Baidal. "Data from our study and long-term follow up of additional omental islet transplants will determine the safety and feasibility of this strategy of islet transplantation, but we are quite excited about what we are seeing now."The findings published in New England Journal of Medicine.

Sharing

advertisement
Videos