Scientists explain link between fatty liver, diabetes & PCOS
Posted July 1st, 2017, 12:20 PM IST
The researchers found an enzyme, AKR1C3---that activates male hormone in the fat tissue of women with PCOS---has been identified, which could rise the risk of metabolic health complications, including Type-2 diabetes and fatty liver disease. According to researchers from the University of Birmingham, the enzyme "causes increased activation of male hormones" in women with PCOS.
In addition to irregular periods and often impaired fertility, PCOS women regularly have high levels of male hormones, also termed androgens, circulating in their blood. These are known to cause problems with increased male-pattern body hair growth and acne.
Women with PCOS often have higher levels of male hormones circulating in the blood and the study has showed that hormones in abdominal fat tissue far exceed those measured in their blood. Lead study author Wiebke Arlt said that the increased activation of male hormones, which lead to increased build-up of lipid droplets in the fat cells and, eventually, to fatty acid overspill into the circulation.
Arlt explained that the fat cells become less responsive and greater levels of insulin are produced. This increased insulin then leads to even higher levels of AKR1C3.
Another researcher Dr Michael O'Reilly explained that the study is particularly exciting because it highlights the role that body fat plays in generating excess male hormones in PCOS women, which then act locally to disrupt the ability of the body's fat to store lipid effectively. "The finding provides a new treatment that reduces the risk of diabetes and fatty liver disease in women with PCOS," O'Reilly said. The study appears in the journal of Clinical Endocrinology & Metabolism.
- Kukatpally, Old City and Tolichowki made their mark as the city's top street food hubs
- Political leaders attend grand Alia Balai programme in Hyderabad
- Over 7,500 daily steps before surgery tied to fewer complications
- Deepika talks mental health with corporate bosses
- Sweet Shop - Owners of Calcutta and Other Ideas: Taste the universe
- Life in motion
- Witness The Most Riveting Courtroom Drama of The Year
- Mind-Body Synergy: Embracing Profound Connection Between Mental and Physical Health
- Red Haute Alert
- WWF-India Hosts Second Earth Series Talk: "A Tale of Two Cats"
- Hyderabad entrepreneurs ‘Modify’ clothes from aloe vera to orange peel
- How to Apply Onion Juice to Hair
- Patriotism is in thing, it’s Tricolour everywhere
- Celebs too wear fakes of reputed brands
- Elon Musk on fun trail says 'buying Coca Cola next'
More Lifestyle News
- Mumbai: Youth arrested for booking cab under gangster Lawrence Bishnoi from Salman Khan’s residence
- Vijay Sethupathi’s heartwarming selfie with elderly voter goes viral
- ‘aha’ unveils promo for ‘Sarkaar Season 4’ featuring Sudigali Sudheer as host
- Record rains in UAE flood Dubai International Airport, disrupt travels
- Akshay Kumar joins Vishnu Manchu’s ‘Kannappa’ shoot in Hyderabad
- Suhana Khan shares joyful photos with Ananya Panday after KKR victory
- Kartik Aaryan says he’s ready for love, asks Neha Dhupia to find someone for him
- Indian film stars extend Ugadi, Gudi Padwa, and Navreh wishes
- Mrunal Thakur honored for ‘Hi Nanna’ performance, details inside
- Prithviraj-starrer ‘The Goat Life’ rakes it in: Rs 100 cr in 9 days
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(): http:// wrapper is disabled in the server configuration by allow_url_fopen=0
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(http://www.indiaaffiliates.in/ads.php?size=300X250): failed to open stream: no suitable wrapper could be found
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once