Researchers discover atomic structure of Alzheimer causing protein
Posted July 6th, 2017, 12:35 PM IST
Using a technique known as cryo-electron microscopy, a team from Britain's Medical Research Council Laboratory of Molecular Biology mapped in fine detail the tau filaments extracted from the brain of a patient who had died with Alzheimer's.
The most common neurodegenerative disease, Alzheimer's is characterized by two types of abnormal protein which form lesions or clumps in the brain. Tau forms filaments inside nerve cells and amyloid-beta forms filaments outside.
In healthy brains tau protein normally helps brain cells to function but in the brains of people with Alzheimer's disease tau clumps up in tangles inside the cells.
"Knowing which parts of tau are important for filament formation is relevant for the development of drugs," said Sjors Scheres, who co-led the research.
Since many pharmaceutical companies are using different parts of tau to test the effect of potential drugs on filament formation, this new knowledge "should significantly increase the accuracy of such tests," he said.
Specialists not directly involved in the study, which was published in the journal Nature, said its findings would prove extremely important in future.
"This study could take us into a new era of drug design," said James Pickett, head of research at the Alzheimer's Society medical charity - although he noted it can take 10 to 15 years to develop new medicines from this early stage of discovery.
John Hardy, a professor of neuroscience at University College London said the work was a "tour de force" which "will help us understand the pathogenesis of Alzheimer's".
- Kukatpally, Old City and Tolichowki made their mark as the city's top street food hubs
- Political leaders attend grand Alia Balai programme in Hyderabad
- Over 7,500 daily steps before surgery tied to fewer complications
- Deepika talks mental health with corporate bosses
- Sweet Shop - Owners of Calcutta and Other Ideas: Taste the universe
- Life in motion
- Witness The Most Riveting Courtroom Drama of The Year
- Mind-Body Synergy: Embracing Profound Connection Between Mental and Physical Health
- Red Haute Alert
- WWF-India Hosts Second Earth Series Talk: "A Tale of Two Cats"
- Hyderabad entrepreneurs ‘Modify’ clothes from aloe vera to orange peel
- How to Apply Onion Juice to Hair
- Patriotism is in thing, it’s Tricolour everywhere
- Celebs too wear fakes of reputed brands
- Elon Musk on fun trail says 'buying Coca Cola next'
More Lifestyle News
- Vijay Sethupathi’s heartwarming selfie with elderly voter goes viral
- ‘aha’ unveils promo for ‘Sarkaar Season 4’ featuring Sudigali Sudheer as host
- Record rains in UAE flood Dubai International Airport, disrupt travels
- Akshay Kumar joins Vishnu Manchu’s ‘Kannappa’ shoot in Hyderabad
- Suhana Khan shares joyful photos with Ananya Panday after KKR victory
- Kartik Aaryan says he’s ready for love, asks Neha Dhupia to find someone for him
- Indian film stars extend Ugadi, Gudi Padwa, and Navreh wishes
- Mrunal Thakur honored for ‘Hi Nanna’ performance, details inside
- Prithviraj-starrer ‘The Goat Life’ rakes it in: Rs 100 cr in 9 days
- Rashmika Mandanna’s ‘Srivalli’ takes center stage in Pushpa 2: The Rule poster drop
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(): http:// wrapper is disabled in the server configuration by allow_url_fopen=0
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(http://www.indiaaffiliates.in/ads.php?size=300X250): failed to open stream: no suitable wrapper could be found
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once