Experts discover genetic cause of rare high blood pressure syndrome
Posted February 7th, 2018, 02:24 PM IST
Professor Ute Scholl and a team of scientists from the United States and Australia have now identified a new hypertension disease gene. The study focused on a particular and very rare form of high blood pressure, known as familial hyper aldosteronism type II.
This inherited disease causes the adrenal gland to produce high level of aldosterone - a hormone that regulates the water and salt conservation in the kidneys. Excess of this hormone in the body shoots up the blood pressure.
According to the research, more than a billion people worldwide suffer from hypertension or high blood pressure. Such a condition, if prolonged, damages blood vessels, which can result in damage to the heart, the kidneys, and the brain.
Possible consequences may include heart attack, kidney failure and stroke. Besides obesity, salt consumption and alcohol intake, genetic factors play an important role in the development of hypertension.
In some rare cases, familial hypertension is caused by mutations within single genes. These genes play important roles in blood pressure determination. These mutations typically cause early-onset hypertension, even in young children and adolescents.
Type II of familial hyperaldosteronism was first described in an Australian family 25 years ago. The research team investigated this family along with other patients suffering from hyperaldosteronism in childhood and adolescence.
A total of eight families, including the large Australian family, showed mutations in a gene that had not previously been associated with blood pressure regulation. The CLCN2 gene carries information for building a channel in the cell membrane through which chloride ions can pass.
In specific cells of the adrenal gland, these chloride channels regulate membrane voltage and aldosterone production. Gene mutations in patients with familial hyperaldosteronism cause changes in the membrane voltage and result in the overproduction of aldosterone, which raises blood pressure.
The findings from this study have been published in the scientific journal Nature Genetics.
- Kukatpally, Old City and Tolichowki made their mark as the city's top street food hubs
- Political leaders attend grand Alia Balai programme in Hyderabad
- Over 7,500 daily steps before surgery tied to fewer complications
- Deepika talks mental health with corporate bosses
- Sweet Shop - Owners of Calcutta and Other Ideas: Taste the universe
- Life in motion
- Witness The Most Riveting Courtroom Drama of The Year
- Mind-Body Synergy: Embracing Profound Connection Between Mental and Physical Health
- Red Haute Alert
- WWF-India Hosts Second Earth Series Talk: "A Tale of Two Cats"
- Hyderabad entrepreneurs ‘Modify’ clothes from aloe vera to orange peel
- How to Apply Onion Juice to Hair
- Patriotism is in thing, it’s Tricolour everywhere
- Celebs too wear fakes of reputed brands
- Elon Musk on fun trail says 'buying Coca Cola next'
More Lifestyle News
- ‘aha’ unveils promo for ‘Sarkaar Season 4’ featuring Sudigali Sudheer as host
- Record rains in UAE flood Dubai International Airport, disrupt travels
- Akshay Kumar joins Vishnu Manchu’s ‘Kannappa’ shoot in Hyderabad
- Suhana Khan shares joyful photos with Ananya Panday after KKR victory
- Kartik Aaryan says he’s ready for love, asks Neha Dhupia to find someone for him
- Indian film stars extend Ugadi, Gudi Padwa, and Navreh wishes
- Mrunal Thakur honored for ‘Hi Nanna’ performance, details inside
- Prithviraj-starrer ‘The Goat Life’ rakes it in: Rs 100 cr in 9 days
- Rashmika Mandanna’s ‘Srivalli’ takes center stage in Pushpa 2: The Rule poster drop
- Deepika Padukone’s ‘Deewani Mastani’ featured on Oscars’ Instagram; Ranveer Singh reacts
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(): http:// wrapper is disabled in the server configuration by allow_url_fopen=0
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: file_get_contents(http://www.indiaaffiliates.in/ads.php?size=300X250): failed to open stream: no suitable wrapper could be found
Filename: views/newsdetails.php
Line Number: 29
Backtrace:
File: /home5/am2pm/public_html/application/views/newsdetails.php
Line: 29
Function: file_get_contents
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 135
Function: view
File: /home5/am2pm/public_html/application/controllers/News.php
Line: 83
Function: newsdetails
File: /home5/am2pm/public_html/index.php
Line: 315
Function: require_once