Why fish can be your heart's best friend
Posted January 13th, 2015, 06:09 PM IST
Researcher David Lambert from the University of to the review of fish peptide to pull together the vast literature on Urotensin II (UII), a peptide first isolated from teleost fish.
UII activates a G protein-coupled receptor called UT to modulate a number of signalling pathways including intracellular Calcium. Interestingly, the peptide can constrict some blood vessels yet dilate others.
The review has shown that UII can modulate a vast array of biologic activities encompassing the cardiovascular system, kidneys and central nervous system.
Lambert said that they have been working on this exciting peptide for a number of years; it exhibits a very interesting pharmacological profile. Design and evaluation of small molecule drugs has potential for use in the treatment of several cardiovascular diseases.
The study published in the journal Pharmacological Reviews.
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